InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAT2B

Summary

InnateDB Protein

IDBP-56647.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAT2B

Protein Name

methionine adenosyltransferase II, beta

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000280969

InnateDB Gene

IDBG-56645 (MAT2B)

Protein Structure

UniProt Annotation

Function

Non-catalytic regulatory subunit of S-adenosylmethionine synthetase 2 (MAT2A), an enzyme that catalyzes the formation of S- adenosylmethionine from methionine and ATP. Regulates the activity of S-adenosylmethionine synthetase 2 by changing its kinetic properties, rendering the enzyme more susceptible to S- adenosylmethionine inhibition. {ECO:0000269PubMed:10644686}.

Subcellular Localization

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:10644686, ECO:0000269PubMed:11337507}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.

Experimentally validated
Total	34 [view]
Protein-Protein	31 [view]
Protein-DNA	2 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity
GO:0008831	dTDP-4-dehydrorhamnose reductase activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0019899	enzyme binding
GO:0048270	methionine adenosyltransferase regulator activity
GO:0050662	coenzyme binding

Biological Process

GO:0000096	sulfur amino acid metabolic process
GO:0006556	S-adenosylmethionine biosynthetic process
GO:0006694	steroid biosynthetic process
GO:0006730	one-carbon metabolic process
GO:0006805	xenobiotic metabolic process
GO:0009058	biosynthetic process
GO:0032259	methylation
GO:0034641	cellular nitrogen compound metabolic process
GO:0044281	small molecule metabolic process
GO:0045226	extracellular polysaccharide biosynthetic process
GO:0050790	regulation of catalytic activity
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005829	cytosol
GO:0048269	methionine adenosyltransferase complex

Protein Structure and Domains

PDB ID

InterPro

IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain
IPR002225 3-beta hydroxysteroid dehydrogenase/isomerase
IPR003869 Polysaccharide biosynthesis protein, CapD-like domain
IPR005913 dTDP-4-dehydrorhamnose reductase

PFAM

PF01370
PF01073
PF02719
PF04321

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9NZL9

PhosphoSite