InnateDB Protein
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IDBP-56703.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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B4GALT1
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Protein Name
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UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
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Synonyms
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B4GAL-T1; beta4Gal-T1; CDG2D; GGTB2; GT1; GTB;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000369055
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InnateDB Gene
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IDBG-56701 (B4GALT1)
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Protein Structure
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Function |
The Golgi complex form catalyzes the production of lactose in the lactating mammary gland and could also be responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.The cell surface form functions as a recognition molecule during a variety of cell to cell and cell to matrix interactions, as those occurring during development and egg fertilization, by binding to specific oligosaccharide ligands on opposing cells or in the extracellular matrix.
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Subcellular Localization |
Isoform Long: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Cell membrane; Single-pass type II membrane protein. Cell surface. Note=Found in trans cisternae of Golgi.Isoform Short: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Found in trans cisternae of Golgi.Processed beta-1,4-galactosyltransferase 1: Secreted. Note=Soluble form found in body fluids.
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Disease Associations |
Congenital disorder of glycosylation 2D (CDG2D) [MIM:607091]: A multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N- glycoproteins during embryonic development, differentiation, and maintenance of cell functions. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
Ubiquitously expressed, but at very low levels in fetal and adult brain.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
13
[view]
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Protein-Protein |
11
[view]
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Protein-DNA |
0
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Protein-RNA |
2
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR003859
Beta-1,4-galactosyltransferase
IPR027791
Galactosyltransferase, C-terminal
IPR029044
Nucleotide-diphospho-sugar transferases
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PFAM |
PF02709
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PRINTS |
PR02050
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P15291
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PhosphoSite |
PhosphoSite-P15291
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TrEMBL |
B7ZAH9
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UniProt Splice Variant |
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Entrez Gene |
2683
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UniGene |
Hs.715113
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RefSeq |
NP_001488
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HUGO |
HGNC:924
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OMIM |
137060
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CCDS |
CCDS6535
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HPRD |
00659
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IMGT |
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EMBL |
AK297541
AK312797
AK316294
AL161445
CH471071
D29805
M13701
M22921
M70427
M70428
M70429
M70430
M70431
M70432
U10472
U10473
U10474
X13223
X14085
X55415
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GenPept |
AAA35935
AAA35936
AAA35937
AAA68218
AAA68219
AAA68220
AAB00776
BAA06188
BAG35657
BAG59940
BAH14665
CAA31611
CAA32247
CAA39073
CAA39074
CAD13306
EAW58520
EAW58521
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