Version 5.4
Homo sapiens Protein: OLAH
Summary
InnateDB Protein IDBP-56716.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol OLAH
Protein Name oleoyl-ACP hydrolase
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000367473
InnateDB Gene IDBG-56714 (OLAH)
Protein Structure
UniProt Annotation
Function In fatty acid biosynthesis chain termination and release of the free fatty acid product is achieved by hydrolysis of the thio ester by a thioesterase I, a component of the fatty acid synthetase complex. The chain length of the released fatty acid is usually C16. However, in the mammary glands of non-ruminant mammals, and in the uropygial gland of certain waterfowl there exists a second thioesterase which releases medium-chain length fatty acids (C8 to C2) (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity Isoform 2 is up-regulated in bone marrow- derived mononuclear cells of rheumatoid arthritis patients. {ECO:0000269PubMed:17082220}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004320 oleoyl-[acyl-carrier-protein] hydrolase activity
GO:0016295 myristoyl-[acyl-carrier-protein] hydrolase activity
GO:0016296 palmitoyl-[acyl-carrier-protein] hydrolase activity
GO:0016788 hydrolase activity, acting on ester bonds
Biological Process
GO:0006633 fatty acid biosynthetic process
GO:0009058 biosynthetic process
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR001031 Thioesterase
IPR029058 Alpha/Beta hydrolase fold
PFAM PF00975
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NV23
PhosphoSite PhosphoSite-Q9NV23
TrEMBL Q5VUB9
UniProt Splice Variant
Entrez Gene 55301
UniGene Hs.24309
RefSeq NP_001034791
HUGO HGNC:25625
OMIM
CCDS CCDS31152
HPRD 07731
IMGT
EMBL AK001844 AK001968 AL157391 AL590365 BC050372 BR000403 CH471072
GenPept AAH50372 BAA91937 BAA92007 CAH73961 CAH73962 EAW86244 EAW86245 FAA00320

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca