Version 5.4
Homo sapiens Protein: IFT81
Summary
InnateDB Protein IDBP-56860.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IFT81
Protein Name intraflagellar transport 81 homolog (Chlamydomonas)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000355372
InnateDB Gene IDBG-56856 (IFT81)
Protein Structure
UniProt Annotation
Function Component of the intraflagellar transport (IFT) complex B: together with IFT74, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds tubulin via its CH (calponin-homology)-like region. Required for ciliogenesis. {ECO:0000269PubMed:23990561}.
Subcellular Localization Cell projection, cilium {ECO:0000305PubMed:23990561}.
Disease Associations
Tissue Specificity Highly expressed in testis, moderately in ovary, heart, liver, skeletal muscle, kidney and pancreas, low in prostate, brain, placenta and lung and not detected in spleen, thymus, small intestine and colon. Isoform CDV-1R is abundantly expressed in testis. {ECO:0000269PubMed:12549821}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0015631 tubulin binding
Biological Process
GO:0007283 spermatogenesis
GO:0035735 intraciliary transport involved in cilium morphogenesis
GO:0042384 cilium assembly
Cellular Component
GO:0005813 centrosome
GO:0005929 cilium
GO:0030992 intraciliary transport particle B
GO:0031514 motile cilium
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8WYA0
PhosphoSite PhosphoSite-Q8WYA0
TrEMBL
UniProt Splice Variant
Entrez Gene 28981
UniGene Hs.528382
RefSeq NP_113661
HUGO HGNC:14313
OMIM 605489
CCDS CCDS9142
HPRD 09266
IMGT
EMBL AF078932 AF139540 AF250326 AF332010 AK091549 BC004536 BC029349 BC108257 CH471054
GenPept AAD48091 AAH04536 AAH29349 AAI08258 AAL50343 AAO32947 AAP97269 BAC03690 EAW97898

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca