InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ACAD11

Summary

InnateDB Protein

IDBP-56900.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACAD11

Protein Name

acyl-CoA dehydrogenase family, member 11

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000264990

InnateDB Gene

IDBG-402582 (ACAD11)

Protein Structure

UniProt Annotation

Function

Acyl-CoA dehydrogenase, that exhibits maximal activity towards saturated C22-CoA. {ECO:0000269PubMed:21237683}.

Subcellular Localization

Peroxisome {ECO:0000250}. Mitochondrion {ECO:0000269PubMed:21237683}. Note=Has been detected associated with mitochondrial membrane, but no matrix, in kidney and cerebellum, as well as in a neuroblastoma cell line, but not in skin fibroblasts, where it is observed in cytoplasmic vesicles (PubMed:21237683). No mitochondrial targeting signals could be predicted for any known isoform, including a putative isoform starting at Met-316. {ECO:0000269PubMed:21237683}.

Disease Associations

Tissue Specificity

Widely expressed with highest levels in brain followed by liver, heart and kidney. {ECO:0000269PubMed:21237683}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003995	acyl-CoA dehydrogenase activity
GO:0004466	long-chain-acyl-CoA dehydrogenase activity
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0017099	very-long-chain-acyl-CoA dehydrogenase activity
GO:0050660	flavin adenine dinucleotide binding
GO:0070991	medium-chain-acyl-CoA dehydrogenase activity

Biological Process

GO:0008152	metabolic process
GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005777	peroxisome
GO:0031966	mitochondrial membrane

Protein Structure and Domains

PDB ID

InterPro

IPR002575 Aminoglycoside phosphotransferase
IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain
IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal
IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain
IPR011009 Protein kinase-like domain
IPR013107 Acyl-CoA dehydrogenase, C-terminal domain
IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal

PFAM

PF01636
PF02770
PF00441
PF08028
PF02771

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q709F0

PhosphoSite