InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ARPC3

Summary

InnateDB Protein

IDBP-57070.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARPC3

Protein Name

actin related protein 2/3 complex, subunit 3, 21kDa

Synonyms

ARC21; p21-Arc;

Species

Homo sapiens

Ensembl Protein

ENSP00000228825

InnateDB Gene

IDBG-57068 (ARPC3)

Protein Structure

UniProt Annotation

Function

Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.

Subcellular Localization

Cytoplasm, cytoskeleton. Cell projection.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	41 [view]
Protein-Protein	41 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005200	structural constituent of cytoskeleton
GO:0005515	protein binding

Biological Process

GO:0006928	cellular component movement
GO:0030833	regulation of actin filament polymerization
GO:0034314	Arp2/3 complex-mediated actin nucleation
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0045087	innate immune response

Cellular Component

GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005885	Arp2/3 protein complex
GO:0015629	actin cytoskeleton
GO:0016020	membrane
GO:0030027	lamellipodium
GO:0070062	extracellular vesicular exosome