Version 5.4
Homo sapiens Protein: FOXI1
Summary
InnateDB Protein IDBP-57201.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FOXI1
Protein Name forkhead box I1
Synonyms FKH10; FKHL10; FREAC-6; FREAC6; HFH-3; HFH3;
Species Homo sapiens
Ensembl Protein ENSP00000304286
InnateDB Gene IDBG-57199 (FOXI1)
Protein Structure
UniProt Annotation
Function Transcriptional activator required for the development of normal hearing, sense of balance and kidney function. Required for the expression of SLC26A4/PDS, JAG1 and COCH in a subset of epithelial cells and the development of the endolymphatic system in the inner ear. Also required for the expression of SLC4A1/AE1, SLC4A9/AE4, ATP6V1B1 and the differentiation of intercalated cells in the epithelium of distal renal tubules (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus.
Disease Associations
Tissue Specificity Expressed in kidney.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0008301 DNA binding, bending
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0009790 embryo development
GO:0042472 inner ear morphogenesis
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR001766 Transcription factor, fork head
PFAM PF00250
PRINTS PR00053
PIRSF
SMART SM00339
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q12951
PhosphoSite PhosphoSite-Q12951
TrEMBL E0XEN6
UniProt Splice Variant
Entrez Gene 2299
UniGene Hs.87236
RefSeq NP_036320
HUGO HGNC:3815
OMIM 601093
CCDS CCDS4372
HPRD 03057
IMGT
EMBL AY707089 BC029778 CH471062 GU049150 GU049151 GU049152 GU049153 GU049154 GU049155 GU049156 GU049157 GU049158 GU049159 GU049160 GU049161 GU049162 GU049163 GU049164 GU049165 GU049166 GU049167 GU049168 GU049169 GU049170 GU049171 GU049172 GU049173 GU049174 GU049175 GU049176 GU049177 GU049178 GU049179 GU049180 GU049181 GU049182 GU049183 GU049184 GU049185 GU049186 GU049187 GU049188 GU049189 GU049190 GU049191 GU049192 GU049193 GU049194 GU049195 GU049196 GU049197 GU049198 GU049199 GU049200 GU049201 GU049202 GU049203 GU049204 GU049205 GU049206 GU049207 GU049208 GU049209 GU049210 GU049211 GU049212 GU049213 GU049214 GU049215 GU049216 GU049217 GU049218 GU049219 GU049220 GU049221 GU049222 GU049223 GU049224 GU049225 GU049226 GU049227 GU049228 GU049229 GU049230 GU049231 GU049232 GU049233 GU049234 GU049235 GU049236 GU049237 GU049238 GU049239 GU049240 GU049241 GU049242 GU049243 GU049244 GU049245 GU049246 GU049247 GU049248 GU049249 GU049250 GU049251 GU049252 GU049254 GU049255 GU049256 GU049257 GU049258 GU049259 GU049260 GU049261 GU049262 GU049263 GU049264 GU049265 GU049266 GU049267 GU049268 GU049269 L13203 U13224
GenPept AAA92041 AAB50574 AAH29778 AAU12169 ADN03217 ADN03218 ADN03219 ADN03220 ADN03221 ADN03222 ADN03223 ADN03224 ADN03225 ADN03226 ADN03227 ADN03228 ADN03229 ADN03230 ADN03231 ADN03232 ADN03233 ADN03234 ADN03235 ADN03236 ADN03237 ADN03238 ADN03239 ADN03240 ADN03241 ADN03242 ADN03243 ADN03244 ADN03245 ADN03246 ADN03247 ADN03248 ADN03249 ADN03250 ADN03251 ADN03252 ADN03253 ADN03254 ADN03255 ADN03256 ADN03257 ADN03258 ADN03259 ADN03260 ADN03261 ADN03262 ADN03263 ADN03264 ADN03265 ADN03266 ADN03267 ADN03268 ADN03269 ADN03270 ADN03271 ADN03272 ADN03273 ADN03274 ADN03275 ADN03276 ADN03277 ADN03278 ADN03279 ADN03280 ADN03281 ADN03282 ADN03283 ADN03284 ADN03285 ADN03286 ADN03287 ADN03288 ADN03289 ADN03290 ADN03291 ADN03292 ADN03293 ADN03294 ADN03295 ADN03296 ADN03297 ADN03298 ADN03299 ADN03300 ADN03301 ADN03302 ADN03303 ADN03304 ADN03305 ADN03306 ADN03307 ADN03308 ADN03309 ADN03310 ADN03311 ADN03312 ADN03313 ADN03314 ADN03315 ADN03316 ADN03317 ADN03318 ADN03319 ADN03321 ADN03322 ADN03323 ADN03324 ADN03325 ADN03326 ADN03327 ADN03328 ADN03329 ADN03330 ADN03331 ADN03332 ADN03333 ADN03334 ADN03335 ADN03336 EAW61490

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca