InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MARK4

Summary

InnateDB Protein

IDBP-57221.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MARK4

Protein Name

MAP/microtubule affinity-regulating kinase 4

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000300843

InnateDB Gene

IDBG-57219 (MARK4)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Ubiquitous. Isoform 2 is brain-specific. {ECO:0000269PubMed:11326310}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	52 [view]
Protein-Protein	52 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008017	microtubule binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0043015	gamma-tubulin binding
GO:0043130	ubiquitin binding
GO:0050321	tau-protein kinase activity

Biological Process

GO:0000226	microtubule cytoskeleton organization
GO:0001578	microtubule bundle formation
GO:0006468	protein phosphorylation
GO:0007399	nervous system development
GO:0043068	positive regulation of programmed cell death

Cellular Component

GO:0005813	centrosome
GO:0005815	microtubule organizing center
GO:0015630	microtubule cytoskeleton
GO:0043005	neuron projection

Protein Structure and Domains

PDB ID

InterPro

IPR000449 Ubiquitin-associated domain/translation elongation factor EF-Ts, N-terminal
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR009060 UBA-like
IPR011009 Protein kinase-like domain
IPR015940 Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00627
PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00165
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt