InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ITGA8

Summary

InnateDB Protein

IDBP-57235.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITGA8

Protein Name

integrin, alpha 8

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000367316

InnateDB Gene

IDBG-57233 (ITGA8)

Protein Structure

UniProt Annotation

Function

Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons. {ECO:0000269PubMed:12415008, ECO:0000269PubMed:15721307}.

Subcellular Localization

Membrane {ECO:0000269PubMed:24439109}; Single-pass type I membrane protein {ECO:0000269PubMed:24439109}. Cell membrane {ECO:0000269PubMed:24439109}.

Disease Associations

Renal hypodysplasia/aplasia 1 (RHDA1) [MIM:191830]: A perinatally lethal renal disease encompassing a spectrum of kidney development defects, including renal agenesis, bilateral renal aplasia, hypoplasia, (cystic) dysplasia, and severe obstructive uropathy. {ECO:0000269PubMed:24439109}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed in mesenchymal cells, including alveolar myofibroblasts, kidney mesangial cells and hepatic stellar cells and vascular and visceral smooth muscle (at protein level). {ECO:0000269PubMed:10504498, ECO:0000269PubMed:7768999}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0046872	metal ion binding

Biological Process

GO:0001656	metanephros development
GO:0007160	cell-matrix adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0007420	brain development
GO:0007613	memory
GO:0016337	single organismal cell-cell adhesion
GO:0030030	cell projection organization
GO:0030198	extracellular matrix organization
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway
GO:0042472	inner ear morphogenesis
GO:0045184	establishment of protein localization
GO:0048745	smooth muscle tissue development
GO:2000721	positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation

Cellular Component

GO:0005886	plasma membrane
GO:0008305	integrin complex
GO:0014069	postsynaptic density
GO:0032591	dendritic spine membrane
GO:0034678	alpha8-beta1 integrin complex
GO:0043204	perikaryon
GO:0045177	apical part of cell

Protein Structure and Domains

PDB ID

InterPro

IPR000413 Integrin alpha chain
IPR013517 FG-GAP repeat
IPR013519 Integrin alpha beta-propellor
IPR013649 Integrin alpha-2
IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site

PFAM

PF01839
PF14312
PF08441
PF00357

PRINTS

PR01185

PIRSF

SMART

SM00191

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt