Version 5.4
Homo sapiens Protein: FAM89B
Summary
InnateDB Protein IDBP-57297.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FAM89B
Protein Name family with sequence similarity 89, member B
Synonyms LRAP25; MTVR1;
Species Homo sapiens
Ensembl Protein ENSP00000314829
InnateDB Gene IDBG-57295 (FAM89B)
Protein Structure
UniProt Annotation
Function Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. {ECO:0000250}.
Subcellular Localization Isoform 3: Cytoplasm {ECO:0000250}.Isoform 1: Cell surface {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0001222 transcription corepressor binding
Biological Process
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0060392 negative regulation of SMAD protein import into nucleus
Cellular Component
GO:0005737 cytoplasm
GO:0009986 cell surface
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8N5H3
PhosphoSite PhosphoSite-Q8N5H3
TrEMBL
UniProt Splice Variant
Entrez Gene 23625
UniGene
RefSeq NP_690045
HUGO HGNC:16708
OMIM
CCDS CCDS8105
HPRD 10100
IMGT
EMBL AF052151 AP001362 BC023991 BC032373 BM557093
GenPept AAH23991 AAH32373

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca