Version 5.4
Homo sapiens Protein: RTKN
Summary
InnateDB Protein IDBP-57318.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RTKN
Protein Name rhotekin
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000305298
InnateDB Gene IDBG-57314 (RTKN)
Protein Structure
UniProt Annotation
Function Mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells in gastric tumorigenesis. May play a novel role in the organization of septin structures. {ECO:0000269PubMed:10940294, ECO:0000269PubMed:15480428, ECO:0000269PubMed:16007136}.
Subcellular Localization
Disease Associations
Tissue Specificity Highly expressed in prostate, moderately in kidney, heart, brain, spleen, testis, placenta, small intestine, pancreas, skeletal muscle and peripheral blood leukocytes, and weakly in ovary, colon and thymus. Weakly expressed in all normal cell lines tested. Overexpressed in various cancer cell lines. {ECO:0000269PubMed:10873388, ECO:0000269PubMed:15480428}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005095 GTPase inhibitor activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0017049 GTP-Rho binding
Biological Process
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0007266 Rho protein signal transduction
GO:0043086 negative regulation of catalytic activity
Cellular Component
GO:0005575 cellular_component
Protein Structure and Domains
PDB ID
InterPro IPR001849 Pleckstrin homology domain
IPR011072 HR1 rho-binding repeat
PFAM PF00169
PF02185
PRINTS
PIRSF
SMART SM00233
SM00742
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BST9
PhosphoSite PhosphoSite-Q9BST9
TrEMBL
UniProt Splice Variant
Entrez Gene 6242
UniGene Hs.192854
RefSeq NP_149035
HUGO HGNC:10466
OMIM 602288
CCDS CCDS1941
HPRD 03795
IMGT
EMBL AC005041 AF049227 AF290512 BC004558 BC017727
GenPept AAG01181 AAH04558 AAH17727 AAL16767

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca