InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLCO2A1

Summary

InnateDB Protein

IDBP-57430.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLCO2A1

Protein Name

solute carrier organic anion transporter family, member 2A1

Synonyms

MATR1; OATP2A1; PGT; PHOAR2; SLC21A2;

Species

Homo sapiens

Ensembl Protein

ENSP00000311291

InnateDB Gene

IDBG-57428 (SLCO2A1)

Protein Structure

UniProt Annotation

Function

May mediate the release of newly synthesized prostaglandins from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. Transports PGD2, as well as PGE1, PGE2 and PGF2A.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Hypertrophic osteoarthropathy, primary, autosomal recessive, 2 (PHOAR2) [MIM:614441]: A disease characterized by digital clubbing, periostosis, acroosteolysis, painful joint enlargement, and variable features of pachydermia that include thickened facial skin and a thickened scalp. Other developmental anomalies include delayed closure of the cranial sutures and congenital heart disease. {ECO:0000269PubMed:22197487, ECO:0000269PubMed:22331663, ECO:0000269PubMed:22553128, ECO:0000269PubMed:22696055}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Ubiquitous. Significant expression observed in ling, kidney, spleen, and heart. {ECO:0000269PubMed:22331663}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005319	lipid transporter activity
GO:0005515	protein binding
GO:0015132	prostaglandin transmembrane transporter activity

Biological Process

GO:0006810	transport
GO:0006869	lipid transport
GO:0015732	prostaglandin transport
GO:0043252	sodium-independent organic anion transport
GO:0055085	transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR002350 Kazal domain
IPR004156 Organic anion transporter polypeptide OATP
IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain

PFAM

PF00050
PF07648
PF03137
PF07690

PRINTS

PIRSF

SMART

SM00280

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q92959