InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PPP1R13L

Summary

InnateDB Protein

IDBP-57436.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPP1R13L

Protein Name

protein phosphatase 1, regulatory subunit 13 like

Synonyms

IASPP; NKIP1; RAI; RAI4;

Species

Homo sapiens

Ensembl Protein

ENSP00000354218

InnateDB Gene

IDBG-57434 (PPP1R13L)

Protein Structure

UniProt Annotation

Function

Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis. {ECO:0000269PubMed:10336463, ECO:0000269PubMed:12134007, ECO:0000269PubMed:12524540, ECO:0000269PubMed:15489900}.

Subcellular Localization

Cytoplasm. Nucleus. Note=Predominantly cytoplasmic but also nuclear.

Disease Associations

Tissue Specificity

Highly expressed in heart, placenta and prostate. Weakly expressed in brain, liver, skeletal muscle, testis and peripheral blood leukocyte. {ECO:0000269PubMed:10336463}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.

Experimentally validated
Total	22 [view]
Protein-Protein	22 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0042802	identical protein binding