InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PHOSPHO1

Summary

InnateDB Protein

IDBP-57555.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PHOSPHO1

Protein Name

phosphatase, orphan 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000311925

InnateDB Gene

IDBG-57553 (PHOSPHO1)

Protein Structure

UniProt Annotation

Function

Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho). Involved in the generation of inorganic phosphate for bone mineralization.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed at sites of mineralization in bone and cartilage. Highly expressed in osteoblast cell line SaOS-2 which produces a mineralized matrix, but not in MG-63 cell line, which do not mineralize. {ECO:0000269PubMed:15050893}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016462	pyrophosphatase activity
GO:0016791	phosphatase activity
GO:0046872	metal ion binding
GO:0052731	phosphocholine phosphatase activity
GO:0052732	phosphoethanolamine phosphatase activity

Biological Process

GO:0006644	phospholipid metabolic process
GO:0006646	phosphatidylethanolamine biosynthetic process
GO:0006656	phosphatidylcholine biosynthetic process
GO:0008152	metabolic process
GO:0016311	dephosphorylation
GO:0030500	regulation of bone mineralization
GO:0044281	small molecule metabolic process
GO:0046474	glycerophospholipid biosynthetic process

Cellular Component

GO:0005829

cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR006383 HAD-superfamily hydrolase, subfamily IB, PSPase-like
IPR006384 Pyridoxal phosphate phosphatase-related
IPR016965 Phosphatase PHOSPHO-type
IPR023214 HAD-like domain

PFAM

PF06888
PF00702
PF08282
PF13419

PRINTS

PIRSF

PIRSF031051

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8TCT1