InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FOSB

Summary

InnateDB Protein

IDBP-57592.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FOSB

Protein Name

FBJ murine osteosarcoma viral oncogene homolog B

Synonyms

AP-1; G0S3; GOS3; GOSB;

Species

Homo sapiens

Ensembl Protein

ENSP00000245919

InnateDB Gene

IDBG-57590 (FOSB)

Protein Structure

UniProt Annotation

Function

FosB interacts with Jun proteins enhancing their DNA binding activity.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	17 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0008134	transcription factor binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007565	female pregnancy
GO:0009612	response to mechanical stimulus
GO:0032570	response to progesterone
GO:0032870	cellular response to hormone stimulus
GO:0042493	response to drug
GO:0043278	response to morphine
GO:0051412	response to corticosterone
GO:0051591	response to cAMP
GO:0071277	cellular response to calcium ion