InnateDB Protein
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IDBP-57600.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PHB
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Protein Name
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prohibitin
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Synonyms
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HEL-215; HEL-S-54e; PHB1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000300408
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InnateDB Gene
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IDBG-57598 (PHB)
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Protein Structure
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Function |
Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging. {ECO:0000269PubMed:11302691}.
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Subcellular Localization |
Mitochondrion inner membrane {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Widely expressed in different tissues.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 101 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
101
[view]
|
Protein-Protein |
100
[view]
|
Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
GO:0000122
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negative regulation of transcription from RNA polymerase II promoter
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GO:0001649
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osteoblast differentiation
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GO:0006260
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DNA replication
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GO:0006355
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regulation of transcription, DNA-templated
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GO:0007165
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signal transduction
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GO:0008285
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negative regulation of cell proliferation
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GO:0010944
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negative regulation of transcription by competitive promoter binding
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GO:0016575
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histone deacetylation
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GO:0030308
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negative regulation of cell growth
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GO:0042981
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regulation of apoptotic process
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GO:0045892
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negative regulation of transcription, DNA-templated
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GO:0045893
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positive regulation of transcription, DNA-templated
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GO:0050847
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progesterone receptor signaling pathway
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GO:0060766
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negative regulation of androgen receptor signaling pathway
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GO:0071354
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cellular response to interleukin-6
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GO:2000323
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negative regulation of glucocorticoid receptor signaling pathway
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Cellular Component |
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PDB ID |
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InterPro |
IPR000163
Prohibitin
IPR001107
Band 7 protein
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PFAM |
PF01145
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PRINTS |
PR00679
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PIRSF |
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SMART |
SM00244
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TIGRFAMs |
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Modification |
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SwissProt |
P35232
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PhosphoSite |
PhosphoSite-P35232
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TrEMBL |
E9PCW0
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UniProt Splice Variant |
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Entrez Gene |
5245
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UniGene |
|
RefSeq |
NP_002625
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HUGO |
HGNC:8912
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OMIM |
176705
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CCDS |
CCDS11548
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HPRD |
01454
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IMGT |
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EMBL |
AC091180
AK290766
AK302258
AK312649
BC013401
BC095460
BT007411
CH471109
L14272
S85655
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GenPept |
AAB21614
AAH13401
AAH95460
AAO18340
AAP36079
BAF83455
BAG35532
BAG63609
EAW94680
EAW94681
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