InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CASK

Summary

InnateDB Protein

IDBP-57643.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CASK

Protein Name

calcium/calmodulin-dependent serine protein kinase (MAGUK family)

Synonyms

CAGH39; CAMGUK; CMG; FGS4; LIN2; MICPCH; MRXSNA; TNRC8;

Species

Homo sapiens

Ensembl Protein

ENSP00000367396

InnateDB Gene

IDBG-57627 (CASK)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 81 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	81 [view]
Protein-Protein	80 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468

protein phosphorylation

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001478 PDZ domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR004172 L27
IPR011009 Protein kinase-like domain
IPR014775 L27, C-terminal
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF00595
PF13180
PF02828

PRINTS

PR00109

PIRSF

SMART

SM00228
SM00220
SM00569
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt