InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ACAD10

Summary

InnateDB Protein

IDBP-57658.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACAD10

Protein Name

acyl-CoA dehydrogenase family, member 10

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000325137

InnateDB Gene

IDBG-57656 (ACAD10)

Protein Structure

UniProt Annotation

Function

Acyl-CoA dehydrogenase only active with R- and S-2- methyl-C15-CoA. {ECO:0000269PubMed:21237683}.

Subcellular Localization

Disease Associations

Tissue Specificity

Widely expressed with highest expression in fetal brain, followed by heart, muscle, kidney and adult brain. Expression levels varying from isoform to isoform. {ECO:0000269PubMed:15560374, ECO:0000269PubMed:21237683}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003995	acyl-CoA dehydrogenase activity
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016787	hydrolase activity
GO:0050660	flavin adenine dinucleotide binding

Biological Process

GO:0008152	metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739

mitochondrion

Protein Structure and Domains

PDB ID

InterPro

IPR002575 Aminoglycoside phosphotransferase
IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain
IPR006439 HAD hydrolase, subfamily IA
IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal
IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain
IPR011009 Protein kinase-like domain
IPR011945 Predicted HAD-superfamily phosphatase, subfamily IA/Epoxide hydrolase, N-terminal
IPR013107 Acyl-CoA dehydrogenase, C-terminal domain
IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal
IPR023214 HAD-like domain

PFAM