InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: STK10

Summary

InnateDB Protein

IDBP-57661.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STK10

Protein Name

serine/threonine kinase 10

Synonyms

LOK; PRO2729;

Species

Homo sapiens

Ensembl Protein

ENSP00000176763

InnateDB Gene

IDBG-57659 (STK10)

Protein Structure

UniProt Annotation

Function

Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo. {ECO:0000269PubMed:11903060, ECO:0000269PubMed:12639966, ECO:0000269PubMed:19255442}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:19255442}; Peripheral membrane protein {ECO:0000269PubMed:19255442}.

Disease Associations

Testicular germ cell tumor (TGCT) [MIM:273300]: A common malignancy in males representing 95% of all testicular neoplasms. TGCTs have various pathologic subtypes including: unclassified intratubular germ cell neoplasia, seminoma (including cases with syncytiotrophoblastic cells), spermatocytic seminoma, embryonal carcinoma, yolk sac tumor, choriocarcinoma, and teratoma. {ECO:0000269PubMed:16175573}. Note=The disease may be caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Highly expressed in rapidly proliferating tissues (spleen, placenta, and peripheral blood leukocytes). Also expressed in brain, heart, skeletal muscle, colon, thymus, kidney, liver, small intestine and lung. {ECO:0000269PubMed:12639966}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042801	polo kinase kinase activity
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006468	protein phosphorylation
GO:0007049	cell cycle
GO:0023014	signal transduction by phosphorylation
GO:0046777	protein autophosphorylation
GO:0071593	lymphocyte aggregation
GO:2000401	regulation of lymphocyte migration

Cellular Component

GO:0005886	plasma membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR022165 Polo kinase kinase

PFAM

PF00069
PF07714
PF12474

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt