Version 5.4
Homo sapiens Protein: DTD1
Summary
InnateDB Protein IDBP-57700.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DTD1
Protein Name D-tyrosyl-tRNA deacylase 1 homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000366672
InnateDB Gene IDBG-57698 (DTD1)
Protein Structure
UniProt Annotation
Function ATPase involved in DNA replication, may facilitate loading of CDC45 onto pre-replication complexes. May hydrolyze D- tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr), a possible defense mechanism against a harmful effect of D-tyrosine. {ECO:0000269PubMed:15653697, ECO:0000269PubMed:20065034}.
Subcellular Localization Nucleus {ECO:0000269PubMed:15653697, ECO:0000269PubMed:20065034}. Cytoplasm {ECO:0000305}. Note=Associated with chromatin at some replication origins containing functional DNA-unwinding elements.
Disease Associations
Tissue Specificity Expressed in many adult and fetal tissues. Highest levels in testis, ovary, spleen and in adult and fetal brain. {ECO:0000269PubMed:12392168}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0016788 hydrolase activity, acting on ester bonds
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0019478 D-amino acid catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR003732 D-tyrosyl-tRNA(Tyr) deacylase
IPR023509 D-Tyr tRNAtyr deacylase-like domain
PFAM PF02580
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TEA8
PhosphoSite PhosphoSite-Q8TEA8
TrEMBL
UniProt Splice Variant
Entrez Gene 92675
UniGene
RefSeq NP_543010
HUGO HGNC:16219
OMIM 610996
CCDS CCDS13138
HPRD
IMGT
EMBL AF332356 AK074304 AK291440 AL121780 AL121900 BC000599 BC045167 BC100923 BC100924 BC100925 CH471133
GenPept AAH45167 AAI00924 AAI00925 AAI00926 AAL57046 BAB85044 BAF84129 CAH73147 CAI15669 EAX10227 EAX10228

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca