Version 5.4
Homo sapiens Protein: GPR4
Summary
InnateDB Protein IDBP-57787.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GPR4
Protein Name G protein-coupled receptor 4
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000319744
InnateDB Gene IDBG-57785 (GPR4)
Protein Structure
UniProt Annotation
Function Proton-sensing receptor coupled to several G-proteins, including G(s), G(13) and G(q)/G(11) proteins, leading to cAMP production. {ECO:0000269PubMed:12955148, ECO:0000269PubMed:17462861}.
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR002276 G protein-coupled receptor 4 orphan
IPR005464 Psychosine receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019430 7TM GPCR, serpentine receptor class x (Srx)
PFAM PF00001
PF10328
PRINTS PR00237
PR01147
PR01649
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P46093
PhosphoSite PhosphoSite-P46093
TrEMBL
UniProt Splice Variant
Entrez Gene 2828
UniGene Hs.619306
RefSeq NP_005273
HUGO HGNC:4497
OMIM 600551
CCDS CCDS12669
HPRD 02773
IMGT
EMBL AC011480 AK290698 BC067535 BC067536 CH471126 EU432116 L36148 U21051 U35399
GenPept AAA63180 AAA79061 AAA98457 AAH67535 AAH67536 ABY87915 BAF83387 EAW57368

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca