InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DUSP1

Summary

InnateDB Protein

IDBP-57814.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DUSP1

Protein Name

dual specificity phosphatase 1

Synonyms

CL100; HVH1; MKP-1; MKP1; PTPN10;

Species

Homo sapiens

Ensembl Protein

ENSP00000239223

InnateDB Gene

IDBG-57812 (DUSP1)

Protein Structure

UniProt Annotation

Function

Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle. {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed at high levels in the lung, liver placenta and pancreas. Moderate levels seen in the heart and skeletal muscle. Lower levels found in the brain and kidney. {ECO:0000269PubMed:8106404}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	51 [view]
Protein-Protein	38 [view]
Protein-DNA	9 [view]
Protein-RNA	4 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0004726	non-membrane spanning protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0008138	protein tyrosine/serine/threonine phosphatase activity
GO:0008330	protein tyrosine/threonine phosphatase activity
GO:0016791	phosphatase activity
GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity

Biological Process

GO:0000188	inactivation of MAPK activity
GO:0001706	endoderm formation
GO:0006470	protein dephosphorylation
GO:0006979	response to oxidative stress
GO:0009416	response to light stimulus
GO:0010033	response to organic substance
GO:0016311	dephosphorylation
GO:0032355	response to estradiol
GO:0032526	response to retinoic acid
GO:0032870	cellular response to hormone stimulus
GO:0033574	response to testosterone
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0035556	intracellular signal transduction
GO:0035970	peptidyl-threonine dephosphorylation
GO:0042542	response to hydrogen peroxide
GO:0042981	regulation of apoptotic process
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0043407	negative regulation of MAP kinase activity
GO:0043409	negative regulation of MAPK cascade
GO:0045087	innate immune response (InnateDB)
GO:0051384	response to glucocorticoid
GO:0051447	negative regulation of meiotic cell cycle
GO:0051591	response to cAMP
GO:0051592	response to calcium ion
GO:0070373	negative regulation of ERK1 and ERK2 cascade
GO:0071850	mitotic cell cycle arrest
GO:0090266	regulation of mitotic cell cycle spindle assembly checkpoint
GO:2000279	negative regulation of DNA biosynthetic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000340 Dual specificity phosphatase, catalytic domain
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR001763 Rhodanese-like domain
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR008343 Mitogen-activated protein (MAP) kinase phosphatase
IPR020417 Atypical dual specificity phosphatase
IPR020422 Dual specificity phosphatase, subgroup, catalytic domain
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00102
PF00782
PF00581

PRINTS

PR00700
PR01764
PR01908

PIRSF

PIRSF000939

SMART

SM00194
SM00450
SM00404
SM00195

TIGRFAMs

Post-translational Modifications

Modification

Cross-References