Version 5.4
Homo sapiens Protein: ERP29
Summary
InnateDB Protein IDBP-57859.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ERP29
Protein Name endoplasmic reticulum protein 29
Synonyms C12orf8; ERp28; ERp31; HEL-S-107; PDI-DB; PDIA9;
Species Homo sapiens
Ensembl Protein ENSP00000261735
InnateDB Gene IDBG-57857 (ERP29)
Protein Structure
UniProt Annotation
Function Does not seem to be a disulfide isomerase. Plays an important role in the processing of secretory proteins within the endoplasmic reticulum (ER), possibly by participating in the folding of proteins in the ER.
Subcellular Localization Endoplasmic reticulum lumen. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Disease Associations
Tissue Specificity Ubiquitous. Mostly expressed in secretory tissues.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 10 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003756 protein disulfide isomerase activity
GO:0005515 protein binding
Biological Process
GO:0006457 protein folding
GO:0006886 intracellular protein transport
GO:0009306 protein secretion
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0009986 cell surface
GO:0016020 membrane
GO:0042470 melanosome
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR011679 Endoplasmic reticulum, protein ERp29, C-terminal
IPR012336 Thioredoxin-like fold
IPR012883 ERp29, N-terminal
IPR016855 Endoplasmic reticulum, protein ERp29
PFAM PF07749
PF13098
PF13192
PF13462
PF13905
PF07912
PRINTS
PIRSF PIRSF027352
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P30040
PhosphoSite PhosphoSite-P30040
TrEMBL V9HW71
UniProt Splice Variant
Entrez Gene 10961
UniGene Hs.75841
RefSeq NP_006808
HUGO HGNC:13799
OMIM 602287
CCDS CCDS9158
HPRD 03794
IMGT
EMBL AA412124 AC073575 BC101493 BC101495 CH471054 CR541667 FJ224317 X94910
GenPept AAI01494 AAI01496 ACI46009 CAA64397 CAG46468 EAW97990 EAW97991

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca