InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: QPCTL

Summary

InnateDB Protein

IDBP-57931.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

QPCTL

Protein Name

glutaminyl-peptide cyclotransferase-like

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000012049

InnateDB Gene

IDBG-57929 (QPCTL)

Protein Structure

UniProt Annotation

Function

Responsible for the biosynthesis of pyroglutamyl peptides. {ECO:0000269PubMed:18486145, ECO:0000269PubMed:21288892}.

Subcellular Localization

Golgi apparatus membrane {ECO:0000269PubMed:18486145}; Single-pass type I membrane protein {ECO:0000269PubMed:18486145}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.

Experimentally validated
Total	17 [view]
Protein-Protein	15 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008233	peptidase activity
GO:0008270	zinc ion binding
GO:0016603	glutaminyl-peptide cyclotransferase activity

Biological Process

GO:0006508	proteolysis
GO:0017186	peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase

Cellular Component

GO:0000139	Golgi membrane
GO:0005794	Golgi apparatus
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR007484 Peptidase M28

PFAM

PF04389

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9NXS2

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

54814

UniGene

Hs.631556

RefSeq

NP_060129

HUGO

HGNC:25952

OMIM

CCDS

CCDS12672

HPRD

08612

IMGT

EMBL

AC007191 AK000091 AK172764 AK222636 BC011553

GenPept

AAH11553 BAA90938 BAD18747 BAD96356