InnateDB Protein
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IDBP-57936.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CREBRF
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Protein Name
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chromosome 5 open reading frame 41
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000296953
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InnateDB Gene
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IDBG-57934 (CREBRF)
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Protein Structure
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Function |
Acts as a negative regulator of the endoplasmic reticulum stress response or unfolded protein response (UPR). Represses the transcriptional activity of CREB3 during the UPR. Recruits CREB3 into nuclear foci. {ECO:0000269PubMed:18391022}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:18391022}. Note=Colocalizes with CREB3 in nuclear foci.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0003700
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sequence-specific DNA binding transcription factor activity
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GO:0005515
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protein binding
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GO:0043565
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sequence-specific DNA binding
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Biological Process |
GO:0000122
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negative regulation of transcription from RNA polymerase II promoter
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GO:0006351
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transcription, DNA-templated
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GO:0006355
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regulation of transcription, DNA-templated
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GO:0006810
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transport
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GO:0006986
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response to unfolded protein
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GO:0032388
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positive regulation of intracellular transport
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GO:0034976
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response to endoplasmic reticulum stress
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GO:0045732
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positive regulation of protein catabolic process
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GO:0051222
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positive regulation of protein transport
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GO:1900102
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negative regulation of endoplasmic reticulum unfolded protein response
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8IUR6
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PhosphoSite |
PhosphoSite-Q8IUR6
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TrEMBL |
I6L8F1
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UniProt Splice Variant |
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Entrez Gene |
153222
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UniGene |
Hs.695015
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RefSeq |
NP_705835
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HUGO |
HGNC:24050
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OMIM |
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CCDS |
CCDS34293
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HPRD |
17308
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IMGT |
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EMBL |
AC008378
AK122675
AK124117
AY139008
AY174896
AY635785
BC041709
BX647573
BX647768
CH471062
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GenPept |
AAH41709
AAN28956
AAO18732
AAV34175
BAG53659
BAG54011
CAI46039
CAI46104
EAW61414
EAW61415
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