InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RIN2

Summary

InnateDB Protein

IDBP-57969.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RIN2

Protein Name

Ras and Rab interactor 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000255006

InnateDB Gene

IDBG-57967 (RIN2)

Protein Structure

UniProt Annotation

Function

Ras effector protein. May function as an upstream activator and/or downstream effector for RAB5B in endocytic pathway. May function as a guanine nucleotide exchange (GEF) of RAB5B, required for activating the RAB5 proteins by exchanging bound GDP for free GTP. {ECO:0000269PubMed:11733506}.

Subcellular Localization

Cytoplasm {ECO:0000305}.

Disease Associations

MACS syndrome (MACS) [MIM:613075]: A complex disorder of elastic tissue characterized by sagging skin and occasionally by life-threatening visceral complications. {ECO:0000269PubMed:19631308}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Widely expressed. Expressed in heart, kidney, lung placenta. Expressed at low level in skeletal muscle, spleen and peripheral blood. {ECO:0000269PubMed:11733506}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005083	small GTPase regulator activity
GO:0005096	GTPase activator activity
GO:0017112	Rab guanyl-nucleotide exchange factor activity

Biological Process

GO:0006897	endocytosis
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0032851	positive regulation of Rab GTPase activity
GO:0050790	regulation of catalytic activity

Cellular Component

GO:0005575	cellular_component
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000159 Ras-association
IPR000980 SH2 domain
IPR003123 Vacuolar sorting protein 9
IPR013995 Vacuolar sorting protein 9, subgroup
IPR029071 Ubiquitin-related domain

PFAM

PF00788
PF00017
PF14633
PF02204

PRINTS

PR00401

PIRSF

SMART

SM00314
SM00252
SM00167

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt