InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SEMA4F

Summary

InnateDB Protein

IDBP-58009.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SEMA4F

Protein Name

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F

Synonyms

M-SEMA; m-Sema-M; PRO2353; S4F; SEMAM; SEMAW;

Species

Homo sapiens

Ensembl Protein

ENSP00000350547

InnateDB Gene

IDBG-58007 (SEMA4F)

Protein Structure

UniProt Annotation

Function

Has growth cone collapse activity against retinal ganglion-cell axons. {ECO:0000250}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding

Biological Process

GO:0007267	cell-cell signaling
GO:0007275	multicellular organismal development
GO:0007399	nervous system development
GO:0007411	axon guidance
GO:0030517	negative regulation of axon extension
GO:0031290	retinal ganglion cell axon guidance

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0045202	synapse
GO:0045211	postsynaptic membrane