InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ITGA3

Summary

InnateDB Protein

IDBP-58016.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITGA3

Protein Name

integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)

Synonyms

CD49C; GAP-B3; GAPB3; ILNEB; MSK18; VCA-2; VL3A; VLA3a;

Species

Homo sapiens

Ensembl Protein

ENSP00000007722

InnateDB Gene

IDBG-58012 (ITGA3)

Protein Structure

UniProt Annotation

Function

Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Alpha- 3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. {ECO:0000269PubMed:15181153}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:15611341}; Single-pass type I membrane protein {ECO:0000269PubMed:15611341}. Cell membrane {ECO:0000269PubMed:15611341}; Lipid-anchor {ECO:0000269PubMed:15611341}.

Disease Associations

Interstitial lung disease, nephrotic syndrome, and epidermolysis bullosa, congenital (ILNEB) [MIM:614748]: A multiorgan disorder characterized by congenital nephrotic syndrome, interstitial lung disease, and epidermolysis bullosa. The respiratory and renal features predominate, and lung involvement accounts for the lethal course of the disease. {ECO:0000269PubMed:22512483}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Isoform 1 is widely expressed. Isoform 2 is expressed in brain and heart. In brain, both isoforms are exclusively expressed on vascular smooth muscle cells, whereas in heart isoform 1 is strongly expressed on vascular smooth muscle cells, isoform 2 is detected only on endothelial vein cells. {ECO:0000269PubMed:9111516}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	22 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001968	fibronectin binding
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0019904	protein domain specific binding
GO:0043236	laminin binding
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001764	neuron migration
GO:0007155	cell adhesion
GO:0007160	cell-matrix adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0007507	heart development
GO:0007596	blood coagulation
GO:0007613	memory
GO:0010628	positive regulation of gene expression
GO:0010634	positive regulation of epithelial cell migration
GO:0010811	positive regulation of cell-substrate adhesion
GO:0010976	positive regulation of neuron projection development
GO:0030198	extracellular matrix organization
GO:0031345	negative regulation of cell projection organization
GO:0034698	response to gonadotropin
GO:0042493	response to drug
GO:0045087	innate immune response (InnateDB)
GO:0050900	leukocyte migration
GO:0060135	maternal process involved in female pregnancy

Cellular Component

GO:0005886	plasma membrane
GO:0008305	integrin complex
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016323	basolateral plasma membrane
GO:0030426	growth cone
GO:0034667	integrin alpha3-beta1 complex
GO:0043235	receptor complex
GO:0045202	synapse
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome