Version 5.4
Homo sapiens Protein: CCDC85B
Summary
InnateDB Protein IDBP-58030.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCDC85B
Protein Name coiled-coil domain containing 85B
Synonyms DIPA;
Species Homo sapiens
Ensembl Protein ENSP00000311695
InnateDB Gene IDBG-58028 (CCDC85B)
Protein Structure
UniProt Annotation
Function Functions as a transcriptional repressor. May inhibit the activity of CTNNB1 in a TP53-dependent manner and thus regulate cell growth. May function in adipocyte differentiation, negatively regulating mitotic clonal expansion. {ECO:0000269PubMed:17014843, ECO:0000269PubMed:17873903}.
Subcellular Localization Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Disease Associations
Tissue Specificity Widely expressed including liver.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 143 experimentally validated interaction(s) in this database.
Experimentally validated
Total 143 [view]
Protein-Protein 143 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0030154 cell differentiation
GO:0030308 negative regulation of cell growth
GO:0045599 negative regulation of fat cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
Protein Structure and Domains
PDB ID
InterPro IPR019359 Protein of unknown function DUF2216, coiled-coil
PFAM PF10226
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q15834
PhosphoSite PhosphoSite-Q15834
TrEMBL
UniProt Splice Variant
Entrez Gene 11007
UniGene
RefSeq NP_006839
HUGO HGNC:24926
OMIM 605360
CCDS CCDS8120
HPRD 16101
IMGT
EMBL AK312109 BC008796 CH471076 U63825
GenPept AAB05928 AAH08796 BAG35045 EAW74468

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca