InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FOXA3

Summary

InnateDB Protein

IDBP-58251.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FOXA3

Protein Name

forkhead box A3

Synonyms

FKHH3; HNF3G; TCF3G;

Species

Homo sapiens

Ensembl Protein

ENSP00000304004

InnateDB Gene

IDBG-58249 (FOXA3)

Protein Structure

UniProt Annotation

Function

Transcription factor that is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites (By similarity). Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; binds to and activates transcription from the G6PC promoter. Binds to the CYP3A4 promoter and activates its transcription in cooperation with CEBPA. Binds to the CYP3A7 promoter together with members of the CTF/NF-I family. Involved in regulation of neuronal-specific transcription. May be involved in regulation of spermatogenesis. {ECO:0000250, ECO:0000269PubMed:12695546}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00089, ECO:0000269PubMed:19706729}.

Disease Associations

Tissue Specificity

Expressed in erythroleukemia and hepatoma cell lines and in liver and pancreas. Not expressed in any other cell lines or tissues examined. {ECO:0000269PubMed:8499623}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0008134	transcription factor binding
GO:0019904	protein domain specific binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0001678	cellular glucose homeostasis
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0007283	spermatogenesis
GO:0009267	cellular response to starvation
GO:0016568	chromatin modification
GO:0030154	cell differentiation
GO:0031018	endocrine pancreas development
GO:0045944	positive regulation of transcription from RNA polymerase II promoter