InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MYPOP

Summary

InnateDB Protein

IDBP-58326.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MYPOP

Protein Name

Myb-related transcription factor, partner of profilin

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000325402

InnateDB Gene

IDBG-58324 (MYPOP)

Protein Structure

UniProt Annotation

Function

Transcriptional repressor; DNA-binding protein that specifically recognizes the core sequence 5'-YAAC[GT]G-3'. Dimerization with PFN1 reduces its DNA-binding capacity (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter