InnateDB Protein
|
IDBP-583309.3
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
PGAM5
|
Protein Name
|
phosphoglycerate mutase family member 5
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000438465
|
InnateDB Gene
|
IDBG-404450 (PGAM5)
|
Protein Structure
|
|
Function |
Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2- dependent gene expression. Acts as a central mediator for programmed necrosis induced by TNF, by reactive oxygen species and by calcium ionophore. {ECO:0000269PubMed:18387606, ECO:0000269PubMed:19590015, ECO:0000269PubMed:22265414}.
|
Subcellular Localization |
Mitochondrion outer membrane {ECO:0000269PubMed:18387606}; Single-pass membrane protein {ECO:0000269PubMed:18387606}. Note=Isoform 2 overexpression results in the formation of disconnected punctuate mitochondria distributed throughout the cytoplasm. Isoform 1 overexpression results in the clustering of mitochondria around the nucleus.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
52
[view]
|
Protein-Protein |
52
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
1 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR013078
Histidine phosphatase superfamily, clade-1
IPR029033
Histidine phosphatase superfamily
|
PFAM |
PF00300
|
PRINTS |
|
PIRSF |
|
SMART |
SM00855
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q96HS1
|
PhosphoSite |
PhosphoSite-Q96HS1
|
TrEMBL |
F5GXG4
|
UniProt Splice Variant |
|
Entrez Gene |
192111
|
UniGene |
Hs.102558
|
RefSeq |
NP_001164015
|
HUGO |
HGNC:28763
|
OMIM |
614939
|
CCDS |
CCDS53845
|
HPRD |
14681
|
IMGT |
|
EMBL |
AC135586
AF357523
BC008196
EU249757
|
GenPept |
AAH08196
AAK60627
ABX39494
|
|
|