InnateDB Protein
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IDBP-58355.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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OAS3
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Protein Name
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2'-5'-oligoadenylate synthetase 3, 100kDa
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Synonyms
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p100;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000228928
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InnateDB Gene
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IDBG-58353 (OAS3)
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Protein Structure
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Function |
Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'- oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus (CHIKV), Dengue virus, Sindbis virus (SINV) and Semliki forest virus (SFV). {ECO:0000269PubMed:19056102, ECO:0000269PubMed:19923450, ECO:0000269PubMed:9880533}.
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Subcellular Localization |
Cytoplasm. Nucleus.
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Disease Associations |
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Tissue Specificity |
Present at high level in placenta trophoblast.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
26
[view]
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Protein-Protein |
25
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002934
Nucleotidyl transferase domain
IPR006116
2-5-oligoadenylate synthetase, N-terminal
IPR018952
2\'-5\'-oligoadenylate synthetase 1, domain 2/C-terminal
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PFAM |
PF01909
PF10421
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9Y6K5
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PhosphoSite |
PhosphoSite-Q9Y6K5
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
4940
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UniGene |
Hs.737661
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RefSeq |
NP_006178
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HUGO |
HGNC:8088
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OMIM |
603351
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CCDS |
CCDS44981
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HPRD |
04519
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IMGT |
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EMBL |
AB044545
AC004551
AF063613
AF251351
BC113746
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GenPept |
AAD28543
AAI13747
BAB18647
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