Version 5.4
Homo sapiens Protein: SPRN
Summary
InnateDB Protein IDBP-583604.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPRN
Protein Name shadow of prion protein homolog (zebrafish)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000433712
InnateDB Gene IDBG-93820 (SPRN)
Protein Structure
UniProt Annotation
Function Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.
Disease Associations
Tissue Specificity Mainly expressed in brain. In brain, it is expressed in hippocampus. {ECO:0000269PubMed:14527721}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
Biological Process
GO:0006606 protein import into nucleus
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0031225 anchored component of membrane
GO:0031982 vesicle
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5BIV9
PhosphoSite PhosphoSite-Q5BIV9
TrEMBL
UniProt Splice Variant
Entrez Gene 503542
UniGene Hs.64968
RefSeq NP_001012526
HUGO HGNC:16871
OMIM 610447
CCDS CCDS53589
HPRD 18499
IMGT
EMBL BC040198 BN000518
GenPept AAH40198 CAG34288

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca