InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LTA4H

Summary

InnateDB Protein

IDBP-583653.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LTA4H

Protein Name

leukotriene A4 hydrolase

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000449958

InnateDB Gene

IDBG-51977 (LTA4H)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.

Experimentally validated
Total	15 [view]
Protein-Protein	11 [view]
Protein-DNA	3 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004177	aminopeptidase activity
GO:0004301	epoxide hydrolase activity
GO:0004463	leukotriene-A4 hydrolase activity
GO:0005488	binding
GO:0008233	peptidase activity
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006508	proteolysis
GO:0006691	leukotriene metabolic process
GO:0006954	inflammatory response
GO:0019369	arachidonic acid metabolic process
GO:0019370	leukotriene biosynthetic process
GO:0043171	peptide catabolic process
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR012777 Leukotriene A4 hydrolase
IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal
IPR015211 Peptidase M1, leukotriene A4 hydrolase, aminopeptidase C-terminal
IPR016024 Armadillo-type fold

PFAM

PF01433
PF09127

PRINTS

PR00756

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P09960