Version 5.4
Homo sapiens Protein: SENP1
Summary
InnateDB Protein IDBP-583725.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SENP1
Protein Name SUMO1/sentrin specific peptidase 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000447328
InnateDB Gene IDBG-29677 (SENP1)
Protein Structure
UniProt Annotation
Function Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity. Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity. Deconjugates SUMO2 from MTA1. {ECO:0000269PubMed:10652325, ECO:0000269PubMed:15199155, ECO:0000269PubMed:16253240, ECO:0000269PubMed:16553580, ECO:0000269PubMed:21829689, ECO:0000269PubMed:21965678, ECO:0000269PubMed:23160374}.
Subcellular Localization Nucleus. Cytoplasm. Note=Shuttles between cytoplasm and nucleus.
Disease Associations
Tissue Specificity Highly expressed in testis. Expressed at lower levels in thymus, pancreas, spleen, liver, ovary and small intestine. {ECO:0000269PubMed:15487983}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 34 [view]
Protein-Protein 33 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004175 endopeptidase activity
GO:0005515 protein binding
GO:0008234 cysteine-type peptidase activity
GO:0016929 SUMO-specific protease activity
Biological Process
GO:0006508 proteolysis
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0016925 protein sumoylation
GO:0016926 protein desumoylation
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005925 focal adhesion
GO:0031965 nuclear membrane
Protein Structure and Domains
PDB ID
InterPro IPR003653 Peptidase C48, SUMO/Sentrin/Ubl1
PFAM PF02902
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9P0U3
PhosphoSite PhosphoSite-Q9P0U3
TrEMBL F8VRZ8
UniProt Splice Variant
Entrez Gene 29843
UniGene Hs.741874
RefSeq NP_001254523
HUGO HGNC:17927
OMIM 612157
CCDS CCDS44868
HPRD 07153
IMGT
EMBL AC004801 AC074029 AF149770 AK292060 BC045639
GenPept AAF31171 AAH45639 BAF84749

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca