Version 5.4
Homo sapiens Protein: HADHA
Summary
InnateDB Protein IDBP-583762.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HADHA
Protein Name hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
Synonyms ECHA; GBP; HADH; LCEH; LCHAD; MTPA; TP-ALPHA;
Species Homo sapiens
Ensembl Protein ENSP00000438039
InnateDB Gene IDBG-35125 (HADHA)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 59 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 59 [view]
Protein-Protein 57 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0050662 coenzyme binding
Biological Process
GO:0006631 fatty acid metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR006108 3-hydroxyacyl-CoA dehydrogenase, C-terminal
IPR008927 6-phosphogluconate dehydrogenase, C-terminal-like
PFAM PF00725
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL H0YFD6
UniProt Splice Variant
Entrez Gene 3030
UniGene Hs.516032
RefSeq
HUGO HGNC:4801
OMIM 600890
CCDS
HPRD 02934
IMGT
EMBL AC010896 AC011742
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca