Version 5.4
Homo sapiens Protein: SOAT1
Summary
InnateDB Protein IDBP-583828.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SOAT1
Protein Name sterol O-acyltransferase 1
Synonyms ACACT; ACAT; ACAT-1; ACAT1; SOAT; STAT;
Species Homo sapiens
Ensembl Protein ENSP00000441356
InnateDB Gene IDBG-105106 (SOAT1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000062 fatty-acyl-CoA binding
GO:0004772 sterol O-acyltransferase activity
GO:0005515 protein binding
GO:0015485 cholesterol binding
GO:0034736 cholesterol O-acyltransferase activity
Biological Process
GO:0008203 cholesterol metabolic process
GO:0010742 macrophage derived foam cell differentiation
GO:0010878 cholesterol storage
GO:0033344 cholesterol efflux
GO:0034379 very-low-density lipoprotein particle assembly
GO:0034435 cholesterol esterification
GO:0042632 cholesterol homeostasis
GO:0042986 positive regulation of amyloid precursor protein biosynthetic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR004299 Membrane bound O-acyl transferase, MBOAT
PFAM PF03062
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P35610
PhosphoSite PhosphoSite-P35610
TrEMBL B4DFD8
UniProt Splice Variant
Entrez Gene 6646
UniGene Hs.619551
RefSeq NP_001239441
HUGO HGNC:11177
OMIM 102642
CCDS CCDS58048
HPRD 00033
IMGT
EMBL AK290659 AK294047 AK300551 AL355806 AL451075 AL512326 BC028940 CH471067 L21934
GenPept AAC37532 AAH28940 BAF83348 BAG57399 BAG62257 CAI12676 CAI13574 EAW91043 EAW91044

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca