Version 5.4
Homo sapiens Protein: NOL8
Summary
InnateDB Protein IDBP-583923.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NOL8
Protein Name nucleolar protein 8
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000441300
InnateDB Gene IDBG-76039 (NOL8)
Protein Structure
UniProt Annotation
Function Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells. {ECO:0000269PubMed:14660641, ECO:0000269PubMed:15132771, ECO:0000269PubMed:16963496}.
Subcellular Localization Nucleus, nucleolus {ECO:0000269PubMed:15132771, ECO:0000269PubMed:16963496}. Note=Localizes in the nucleolar-organizing region during ribosome biogenesis.
Disease Associations
Tissue Specificity Expressed in various diffuse-type gastric cancers. Detected at lower levels in skeletal muscle. {ECO:0000269PubMed:15132771}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006260 DNA replication
GO:0006364 rRNA processing
GO:0030307 positive regulation of cell growth
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000504 RNA recognition motif domain
PFAM PF00076
PRINTS
PIRSF
SMART SM00360
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q76FK4
PhosphoSite PhosphoSite-Q76FK4
TrEMBL F5H8B8
UniProt Splice Variant
Entrez Gene 55035
UniGene Hs.442199
RefSeq XP_006717231
HUGO HGNC:23387
OMIM 611534
CCDS
HPRD 11397
IMGT
EMBL AB105104 AB109030 AK000743 AK001049 AK022755 AK024245 AK024786 AL136097 BC013788
GenPept AAH13788 BAA91356 BAA91479 BAB14229 BAB14857 BAB15003 BAC99315 BAD12268

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca