InnateDB Protein
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IDBP-58394.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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OAS2
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Protein Name
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2'-5'-oligoadenylate synthetase 2, 69/71kDa
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000342278
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InnateDB Gene
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IDBG-58392 (OAS2)
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Protein Structure
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Function |
Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. {ECO:0000269PubMed:10464285, ECO:0000269PubMed:19923450, ECO:0000269PubMed:9880569}.
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Subcellular Localization |
Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion. Nucleus. Microsome. Endoplasmic reticulum. Note=Associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
6
[view]
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Protein-Protein |
5
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002934
Nucleotidyl transferase domain
IPR006116
2-5-oligoadenylate synthetase, N-terminal
IPR018952
2\'-5\'-oligoadenylate synthetase 1, domain 2/C-terminal
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PFAM |
PF01909
PF10421
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P29728
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PhosphoSite |
PhosphoSite-P29728
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
4939
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UniGene |
Hs.620043
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RefSeq |
NP_058197
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HUGO |
HGNC:8087
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OMIM |
603350
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CCDS |
CCDS31906
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HPRD |
04518
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IMGT |
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EMBL |
AC004551
AK292796
BC023637
BC049215
CH471054
M87284
M87434
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GenPept |
AAA60606
AAA60607
AAH23637
AAH49215
BAF85485
EAW98027
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