Version 5.4
Homo sapiens Protein: RNF135
Summary
InnateDB Protein IDBP-584013.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RNF135
Protein Name ring finger protein 135
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000440470
InnateDB Gene IDBG-39370 (RNF135)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0043021 ribonucleoprotein complex binding
GO:0046872 metal ion binding
Biological Process
GO:0016567 protein ubiquitination
GO:0032480 negative regulation of type I interferon production
GO:0032728 positive regulation of interferon-beta production
GO:0045087 innate immune response (InnateDB)
GO:0045088 regulation of innate immune response
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR001841 Zinc finger, RING-type
IPR018957 Zinc finger, C3HC4 RING-type
PFAM PF13639
PF14634
PF00097
PRINTS
PIRSF
SMART SM00184
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8IUD6
PhosphoSite PhosphoSite-Q8IUD6
TrEMBL
UniProt Splice Variant
Entrez Gene 84282
UniGene Hs.29874
RefSeq NP_001171921
HUGO HGNC:21158
OMIM 611358
CCDS CCDS54104
HPRD 11506
IMGT
EMBL AB470605 AC138207 AJ496729 AK122646 AK312979 AY598332 BC005084 BC082262 BC126420 BC126422 CH471147
GenPept AAH05084 AAI26421 AAI26423 AAT06743 BAG35816 BAG53638 BAG84604 CAD43140 EAW80286

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca