InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CNOT2

Summary

InnateDB Protein

IDBP-584091.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CNOT2

Protein Name

CCR4-NOT transcription complex, subunit 2

Synonyms

CDC36; NOT2; NOT2H;

Species

Homo sapiens

Ensembl Protein

ENSP00000448883

InnateDB Gene

IDBG-47581 (CNOT2)

Protein Structure

UniProt Annotation

Function

Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specificly involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of emryonic stem (ES) cell identity. {ECO:0000269PubMed:14707134, ECO:0000269PubMed:16712523, ECO:0000269PubMed:21299754, ECO:0000269PubMed:22367759}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:21299754}. Nucleus {ECO:0000305PubMed:21299754}.

Disease Associations

Tissue Specificity

Ubiquitous. Highly expressed in brain, heart, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocytes. {ECO:0000269PubMed:10637334}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.

Experimentally validated
Total	32 [view]
Protein-Protein	30 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001104	RNA polymerase II transcription cofactor activity
GO:0001226	RNA polymerase II transcription corepressor binding
GO:0004535	poly(A)-specific ribonuclease activity
GO:0005515	protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0006417	regulation of translation
GO:0010467	gene expression
GO:0010606	positive regulation of cytoplasmic mRNA processing body assembly
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0031047	gene silencing by RNA
GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic
GO:2000036	regulation of stem cell maintenance