InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: STX17

Summary

InnateDB Protein

IDBP-584226.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STX17

Protein Name

syntaxin 17

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000435981

InnateDB Gene

IDBG-78626 (STX17)

Protein Structure

UniProt Annotation

Function

SNAREs, Soluble N-ethylmaleimide-sensitive factor- attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane. May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediate compartment/ERGIC and Golgi and/or regulate transport between the endoplasmic reticulum, the ERGIC and the Golgi (PubMed:21545355). {ECO:0000269PubMed:21545355, ECO:0000269PubMed:23217709}.

Subcellular Localization

Endoplasmic reticulum membrane; Multi-pass membrane protein. Smooth endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII- coated vesicle membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Note=Has an hairpin-like insertion into membranes. Localized into endoplasmic reticulum membranes, it also localizes to the completed autophagosome membrane upon cell starvation. May also localize to the mitochondria according to PubMed:23217709. A significant amount is also present in the cytosol.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000149	SNARE binding
GO:0005484	SNAP receptor activity
GO:0005515	protein binding
GO:0019903	protein phosphatase binding

Biological Process

GO:0000046	autophagic vacuole fusion
GO:0006886	intracellular protein transport
GO:0006887	exocytosis
GO:0006888	ER to Golgi vesicle-mediated transport
GO:0007030	Golgi organization
GO:0016192	vesicle-mediated transport
GO:0097111	endoplasmic reticulum-Golgi intermediate compartment organization

Cellular Component

GO:0000421	autophagic vacuole membrane
GO:0005739	mitochondrion
GO:0005789	endoplasmic reticulum membrane
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
GO:0005829	cytosol
GO:0012507	ER to Golgi transport vesicle membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030134	ER to Golgi transport vesicle
GO:0030868	smooth endoplasmic reticulum membrane
GO:0031201	SNARE complex
GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane