InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NXF1

Summary

InnateDB Protein

IDBP-584372.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NXF1

Protein Name

nuclear RNA export factor 1

Synonyms

MEX67; TAP;

Species

Homo sapiens

Ensembl Protein

ENSP00000453885

InnateDB Gene

IDBG-51882 (NXF1)

Protein Structure

UniProt Annotation

Function

Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex. ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export. {ECO:0000269PubMed:18364396, ECO:0000269PubMed:19165146, ECO:0000269PubMed:9660949}.

Subcellular Localization

Nucleus, nucleoplasm. Nucleus speckle. Cytoplasm. Note=Localized predominantly in the nucleoplasm and at both the nucleoplasmic and cytoplasmic faces of the nuclear pore complex. Shuttles between the nucleus and the cytoplasm. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. The association with the TREX complex seems to occur in regions surrounding nuclear speckles known as perispeckles.

Disease Associations

Tissue Specificity

Expressed ubiquitously.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 129 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	129 [view]
Protein-Protein	120 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	9 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006406	mRNA export from nucleus
GO:0010467	gene expression
GO:0016032	viral process

Cellular Component

GO:0000346	transcription export complex
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016607	nuclear speck

Protein Structure and Domains

PDB ID

InterPro

IPR001611 Leucine-rich repeat
IPR015245 Nuclear RNA export factor Tap, RNA-binding domain

PFAM

PF00560
PF13504
PF13855
PF09162

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9UBU9

PhosphoSite

PhosphoSite-Q9UBU9

TrEMBL

Q59E96

UniProt Splice Variant

Entrez Gene

10482

UniGene

Hs.623481

RefSeq

NP_001074960

HUGO

HGNC:8071

OMIM

602647

CCDS

CCDS44629

HPRD

04035

IMGT

EMBL

AB209915 AF112880 AF126246 AJ132712 AK027192 AK304082 AK304137 AK304743 AP001160 BC004904 BC028041 CH471076 U80073

GenPept

AAB81111 AAD20016 AAD39102 AAH04904 AAH28041 BAD93152 BAG64989 BAG65031 BAG65502 CAA10753 EAW74105