Version 5.4
Homo sapiens Protein: KIAA0430
Summary
InnateDB Protein IDBP-584659.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KIAA0430
Protein Name KIAA0430
Synonyms LKAP; MARF1; PPP1R34;
Species Homo sapiens
Ensembl Protein ENSP00000449376
InnateDB Gene IDBG-16071 (KIAA0430)
Protein Structure
UniProt Annotation
Function Essential regulator of oogenesis required for female meiotic progression to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Probably acts via some RNA metabolic process, equivalent to the piRNA system in males, which mediates the repression of transposable elements during meiosis by forming complexes composed of RNAs and governs the methylation and subsequent repression of transposons. Also required to protect from DNA double-strand breaks (By similarity). {ECO:0000250}.
Subcellular Localization Peroxisome {ECO:0000269PubMed:15932519}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003674 molecular_function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
Biological Process
GO:0007143 female meiotic division
GO:0010468 regulation of gene expression
GO:0010923 negative regulation of phosphatase activity
GO:0048477 oogenesis
Cellular Component
GO:0005777 peroxisome
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR000504 RNA recognition motif domain
IPR021139 NYN domain, limkain-b1-type
IPR024582 Limkain b1, conserved domain
PFAM PF00076
PF01936
PF11608
PRINTS
PIRSF
SMART SM00360
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y4F3
PhosphoSite PhosphoSite-Q9Y4F3
TrEMBL F8VRS5
UniProt Splice Variant
Entrez Gene 9665
UniGene Hs.673229
RefSeq NP_001171928
HUGO HGNC:29562
OMIM 614593
CCDS CCDS55991
HPRD 13992
IMGT
EMBL AB007890 AB012134 AC026401 AK302667 BC064914 BC137165 BC137170 BC144514 BC144515 CH471226 U95740
GenPept AAC31662 AAH64914 AAI37166 AAI37171 AAI44515 AAI44516 BAA24860 BAB82433 BAG63901 EAW53920

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca