InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BLM

Summary

InnateDB Protein

IDBP-585118.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BLM

Protein Name

Bloom syndrome, RecQ helicase-like

Synonyms

BS; RECQ2; RECQL2; RECQL3;

Species

Homo sapiens

Ensembl Protein

ENSP00000454158

InnateDB Gene

IDBG-30365 (BLM)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 112 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	112 [view]
Protein-Protein	110 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003824	catalytic activity
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0043140	ATP-dependent 3'-5' DNA helicase activity

Biological Process

GO:0006200	ATP catabolic process
GO:0006260	DNA replication
GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0032508	DNA duplex unwinding
GO:0044237	cellular metabolic process

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR001650 Helicase, C-terminal
IPR004589 DNA helicase, ATP-dependent, RecQ type
IPR010997 HRDC-like
IPR011545 DEAD/DEAH box helicase domain
IPR012532 BDHCT
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR018982 RQC domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00271
PF00270
PF08072
PF09382

PRINTS

PIRSF

SMART

SM00490
SM00487
SM00956

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite