InnateDB Protein
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IDBP-585350.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SIGLEC7
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Protein Name
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sialic acid binding Ig-like lectin 7
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000437609
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InnateDB Gene
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IDBG-65680 (SIGLEC7)
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Protein Structure
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Function |
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro). {ECO:0000269PubMed:10611343}.
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Subcellular Localization |
Membrane; Single-pass type I membrane protein.
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Disease Associations |
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Tissue Specificity |
Predominantly expressed by resting and activated natural killer cells and at lower levels by granulocytes and monocytes. High expression found in placenta, liver, lung, spleen, and peripheral blood leukocytes.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR003599
Immunoglobulin subtype
IPR013106
Immunoglobulin V-set domain
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PFAM |
PF07686
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PRINTS |
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PIRSF |
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SMART |
SM00409
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TIGRFAMs |
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Modification |
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SwissProt |
Q9Y286
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PhosphoSite |
PhosphoSite-Q9Y286
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
27036
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UniGene |
Hs.655393
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RefSeq |
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HUGO |
HGNC:10876
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OMIM |
604410
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CCDS |
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HPRD |
05102
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IMGT |
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EMBL |
AF170485
AF178981
AF193441
AJ007395
AJ130710
AJ130711
AJ130712
AJ130713
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GenPept |
AAF06790
AAF12759
AAF44346
CAB46011
CAB51126
CAB51127
CAB51128
CAB51129
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