InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CMKLR1

Summary

InnateDB Protein

IDBP-585387.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CMKLR1

Protein Name

chemokine-like receptor 1

Synonyms

CHEMERINR; ChemR23; DEZ; RVER1;

Species

Homo sapiens

Ensembl Protein

ENSP00000447579

InnateDB Gene

IDBG-55274 (CMKLR1)

Protein Structure

UniProt Annotation

Function

Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF- kappa-B. Positively regulates adipogenesis and adipocyte metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2). {ECO:0000269PubMed:15728234, ECO:0000269PubMed:15753205, ECO:0000269PubMed:20044979, ECO:0000269PubMed:9603476}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:15728234, ECO:0000269PubMed:16863918}; Multi-pass membrane protein {ECO:0000269PubMed:15728234, ECO:0000269PubMed:16863918}.

Disease Associations

Tissue Specificity

Prominently expressed in developing osseous and cartilaginous tissue. Also found in adult parathyroid glands. Expressed in cardiovascular system, brain, kidney, gastrointestinal tissues and myeloid tissues. Expressed in a broad array of tissues associated with hematopoietic and immune function including, spleen, thymus, appendix, lymph node, bone marrow and fetal liver. Among leukocyte populations abundant expression in monocyte-derived macrophage and immature dendritic cells (DCs). High expression in blood monocytes and low levels in polymorphonuclear cells and T-cells. Expressed on endothelial cells. Highly expressed in differentiating adipocytes. {ECO:0000269PubMed:14530373, ECO:0000269PubMed:15728234, ECO:0000269PubMed:15753205, ECO:0000269PubMed:18242188, ECO:0000269PubMed:20044979, ECO:0000269PubMed:8976386}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0004950	chemokine receptor activity
GO:0005515	protein binding

Biological Process

GO:0001501	skeletal system development
GO:0006935	chemotaxis
GO:0006955	immune response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0010759	positive regulation of macrophage chemotaxis
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0032695	negative regulation of interleukin-12 production
GO:0045600	positive regulation of fat cell differentiation
GO:0050848	regulation of calcium-mediated signaling
GO:0070098	chemokine-mediated signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000248 Angiotensin II receptor family
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR002234 Anaphylatoxin chemotactic receptor family
IPR002258 DEZ orphan receptor
IPR017452 GPCR, rhodopsin-like, 7TM

PFAM

PF00001

PRINTS

PR00241
PR00237
PR01104
PR01126

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q99788