InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SOD2

Summary

InnateDB Protein

IDBP-585636.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SOD2

Protein Name

superoxide dismutase 2, mitochondrial

Synonyms

IPOB; MNSOD; MVCD6;

Species

Homo sapiens

Ensembl Protein

ENSP00000442920

InnateDB Gene

IDBG-98553 (SOD2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	21 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004784	superoxide dismutase activity
GO:0030145	manganese ion binding
GO:0042802	identical protein binding
GO:0046872	metal ion binding

Biological Process

GO:0000303	response to superoxide
GO:0001315	age-dependent response to reactive oxygen species
GO:0001836	release of cytochrome c from mitochondria
GO:0003069	vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006801	superoxide metabolic process
GO:0008217	regulation of blood pressure
GO:0008285	negative regulation of cell proliferation
GO:0019430	removal of superoxide radicals
GO:0032364	oxygen homeostasis
GO:0043524	negative regulation of neuron apoptotic process
GO:0051289	protein homotetramerization
GO:0055114	oxidation-reduction process
GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

Cellular Component

GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001189 Manganese/iron superoxide dismutase
IPR019831 Manganese/iron superoxide dismutase, N-terminal
IPR019832 Manganese/iron superoxide dismutase, C-terminal

PFAM

PF00081
PF02777

PRINTS

PR01703

PIRSF

PIRSF000349

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt