InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TDO2

Summary

InnateDB Protein

IDBP-585747.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TDO2

Protein Name

tryptophan 2,3-dioxygenase

Synonyms

TDO; TO; TPH2; TRPO;

Species

Homo sapiens

Ensembl Protein

ENSP00000444788

InnateDB Gene

IDBG-42495 (TDO2)

Protein Structure

UniProt Annotation

Function

Incorporates oxygen into the indole moiety of tryptophan. Has a broad specificity towards tryptamine and derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.

Experimentally validated
Total	14 [view]
Protein-Protein	12 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004833	tryptophan 2,3-dioxygenase activity
GO:0016597	amino acid binding
GO:0019825	oxygen binding
GO:0020037	heme binding
GO:0046872	metal ion binding

Biological Process

GO:0006568	tryptophan metabolic process
GO:0006569	tryptophan catabolic process
GO:0019441	tryptophan catabolic process to kynurenine
GO:0019442	tryptophan catabolic process to acetyl-CoA
GO:0034641	cellular nitrogen compound metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process